ACIP opens door to anthrax shots for first responders

first_imgOct 23, 2008 (CIDRAP News) – The federal Advisory Committee on Immunization Practices (ACIP) has opened the door to voluntary anthrax vaccination for first responders, revising an 8-year-old recommendation against that step.The committee, meeting yesterday, said the risk of anthrax exposure for emergency responders is low but “may not be zero,” and therefore first-responder agencies may want to offer the vaccine on a voluntary basis, according to information supplied by the Centers for Disease Control and Prevention (CDC) today.The CDC routinely adopts the ACIP’s recommendations.Anthrax vaccination—which currently involves six doses over 18 months, followed by annual boosters—is required for US military personnel serving in the Middle East and other high-risk areas. Nearly 2 million service members have been vaccinated under the program, according to ACIP reports.However, a number of military members have complained of negative side effects from the shot, and a lawsuit by several of them interrupted mandatory vaccinations for about 2 years starting in October 2004. Another lawsuit against the program is still in the courts.Allowing the optionThe new recommendation adopted by the ACIP does not actively encourage anthrax shots for first responders. It states:”Emergency and other responders, including police departments, fire departments, hazardous material units, government responders, the National Guard and others, are not recommended for routine pre-event anthrax vaccination. However, the committee recognized that while the risk of exposure for first responders to anthrax is low it may not be zero. Therefore, first responder units may choose to offer their workers pre-event vaccination on a voluntary basis. The vaccination program should be carried out under the direction of a comprehensive occupational health and safety program.”In 2000 the ACIP recommended against “pre-event” anthrax shots for first responders, and that stance was reaffirmed when the committee revisited the issue after the anthrax attacks of late 2001, according to an online summary of the June 2008 ACIP meeting. The reasons for reconsidering that recommendation included a growing supply of the vaccine and new data suggesting a change in the vaccine’s safety profile, plus interest from some first-responder groups, according to comments made at that meeting.Interest from emergency respondersA change in the recommendation for first responders was proposed at the June meeting by an ACIP subcommittee called the Anthrax Vaccine Workgroup. The panel’s work was described by Jennifer G. Wright, DVM, MPH.”Post-event vaccination in combination with antibiotics is an effective intervention following exposure to B[acillus] anthracis spores, but the workgroup felt that pre-event vaccination could offer additional protection beyond that afforded by antibiotics and post[exposure] vaccination by providing early priming of the immune system,” the meeting summary states. “Some respondent organizations have stated that their members would be more willing to respond to a bioterrorism event if they were vaccinated prior to the occurrence of the event.”Dr. Richard Besser, director of the CDC’s Coordinating Office for Terrorism Preparedness and Emergency Response, commented at the June meeting that a number of emergency response agencies had indicated interest in preemptive anthrax immunization for their workers, but the existing negative recommendation was seen as an impediment.Also at that meeting, the CDC’s Nancy Messonier said that the workgroup’s intent in proposing a change was “to open the door, knowing that the vaccine is commercially available and that first responder groups are at liberty to call the manufacture to obtain the vaccine themselves,” the meeting summary states.The FDA-licensed vaccine, called anthrax vaccine adsorbed (AVA) (Biothrax), is made by Emergent BioSolutions Inc. Current annual production capacity is 8 million to 9 million doses, up from about 2 million in 2002, the June meeting report says. A new manufacturing facility that is being tested will eventually boost production to as many as 30 million to 35 million doses, it says.”The workgroup felt that at the current time, vaccine supply was sufficient to support vaccination for a large group of individuals,” the report states. It says the nation may have as many as 3 million first responders, depending on how the term is defined.The work group concluded that the risk of anthrax exposure for first responders through a bioterrorism event is “undefinable,” the summary states. However, the group concluded that the available data suggest that the vaccine is safe and effective.Fewer adverse eventsThrough June 2008, 4,705 reports of adverse events associated with anthrax vaccination of military personnel were filed with the government’s Vaccine Adverse Event Reporting System, the report says. That represents a rate of 61.1 reports per 100,000 doses, as compared with 117 reports per 100,000 doses of smallpox vaccine. About 10% of the reports described “serious” adverse events.The report also said that in February the ACIP looked at data showing a decrease in local adverse events when the vaccine was given intramuscularly rather than by the standard subcutaneous route. That was an apparent reference to interim findings in a CDC study, which were reported in the Oct 1 Journal of the American Medical Association (JAMA; see link to news story below).The JAMA report said people who were vaccinated intramuscularly had fewer injection-site reactions after four doses than those who received subcutaneous shots. It also said those who received three intramuscular shots in the first 6 months had about the same immune response as those who received the standard four subcutaneous shots, suggesting that dose reduction may be possible.Discussion at the June ACIP meeting pointed out the challenges that would be posed by any effort to vaccinate large numbers of first responders, given the number and timing of doses involved. These include determining who would administer the vaccine, tracking recipients to keep them on schedule, providing liability coverage, monitoring adverse events, and caring for those who experience adverse events.Postexposure protectionAt yesterday’s meeting, the CDC reported, the ACIP also made a recommendation on postexposure protection against anthrax: 60 days of antimicrobial treatment in combination with three doses of vaccine. Vaccine should be offered within 10 days of exposure.”Anthrax vaccine is not licensed for children and has not been studied in children,” the CDC update said. “However, postexposure anthrax vaccination in children potentially exposed to anthrax may be considered on an event-by-event basis in conjunction with 60 days of antibiotics.”The recommendation on postexposure prophylaxis includes pregnant women. “Pregnancy is neither a precaution nor a contraindication. Pregnant women should receive vaccine and antibiotics if they are exposed to inhalation anthrax,” the CDC said.See also: Minutes of June 2008 ACIP meeting, including discussion of anthrax vaccinehttp://www.cdc.gov/vaccines/recs/acip/downloads/min-archive/min-jun08.pdfOct 6 CIDRAP News story “Trial offers hope for shortening anthrax-shot series”Oct 2 CIDRAP News story “To blunt anthrax attack, mail carriers to get antibiotics”last_img read more

Wrestling Sectional Results At Franklin County

first_imgThe 2014 Wrestling Sectionals took place at Franklin County High School.South Dearborn won the Team Championship with 185 followed by Franklin County 181, East Central 145, Union County 141, Batesville 120, Connersville 119.5, Milan 114, Rushville 99, and Lawrenceburg 93.5.The Top four wrestlers from each weight class will be advancing to The Regionals on Saturday (2-8) at Richmond.Wrestling Sectionals @ Franklin County 2014Congrats to all of our area wrestlers for an outstanding showing at The Sectionals from Country 103.9 WRBI.Courtesy of The IHSAA.last_img

Football News Robert Lewandowski helps Bayern Munich avoid humiliating exit from German Cup in thrilling tie

first_img Munich: Robert Lewandowski saved his team from a humiliating German Cup exit as Bayern Munich came from behind to beat second-tier Heidenheim in a 5-4 thriller on Wednesday. Bayern was 2-1 down at half-time having gone down to ten men early in the game, and threw away a two-goal lead in the second half. Yet Lewandowski’s late winner ended a rollercoaster resistance from Heidenheim and sent Bayern into the semi-finals. “I don’t really know what to think of this game,” said Bayern striker Thomas Mueller on Sky Sports. “After such a great start, it should have gone differently for us. We didn’t play well, particularly after the red card, and it doesn’t feel all that good.” Everything seemed to be going according to the script when Leon Goretzka headed Bayern in front from a corner on 12 minutes.             Yet the script went up in flames when Bayern went down to ten men just minutes later. Niklas Suele was initially booked for a challenge on Robert Andrich, but a video review convinced the referee that Suele had denied Andrich a goalscoring opportunity. The red card galvanised Heidenheim and they forced several chances before Robert Glatzel headed in the equaliser just before the half-hour mark. Ten minutes later, the Allianz Arena was silenced as Marc Schnatterer fired Heidenheim in front.RELATED      Mueller brought Bayern level after half-time, turning in Lewandowski’s header with a marvellous, swiveling finish. He then returned the favor three minutes later, setting up Lewandowski to restore the lead for Bayern. Serge Gnabry added a fourth for Bayern on 65 minutes, slotting the ball in at the far post at a corner. Yet Glatzel stunned Bayern again when he scored twice in three minutes to make it 4-4. Having pulled a goal back on 74 minutes, the Heidenheim striker completed his hat-trick from the penalty spot.          It ended in disappointment for Heidenheim, however, as a handball at the other end allowed Lewandowski to score the winner with an 84th-minute penalty. Werder Bremen also reached the semi-finals after they eased to a 2-0 win over Schalke thanks to goals from Milot Rashica and Davy Klaassen. Rashica’s dipping shot from outside the area broke the deadlock just after the hour mark. Klaassen slotted in a second shortly afterward to ensure Werder’s place in the last four alongside Bayern, RB Leipzig and old rivals Hamburg.            “We didn’t play very well today but we had the quality to win anyway and we are very happy to be in the semis,” Bremen captain Max Kruse told Sky. The semi-final draw will take place on Sunday. highlights Heidenheim had earlier defeated Schalke in the German Cup.Bayern Munich were reduced to 10 men when Niklas Suele was sent off.Thomas Mueller and Robert Lewandowski were the key.center_img For all the Latest Sports News News, Football News News, Download News Nation Android and iOS Mobile Apps.last_img read more